Inhibition of Idiosyncratic Reactions to Aspirin by Ketotifen
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چکیده
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Inhibition of idiosyncratic reactions to aspirin in asthmatic patients by clemastine.
An H1-receptor blocking antihistamine, clemastine, taken before aspirin gave complete or partial protection against flushing, rhinorrhea, cough, and headache in ten asthmatic patients with idiosyncrasy to aspirin. In five of the ten patients aspirin-precipitated bronchoconstriction was also reduced or prevented after pretreatment with clemastine. Thus histamine appears to play a part in the pro...
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Idiosyncratic drug reactions may be defined as adverse effects that cannot be explained by the known mechanisms of action of the offending agent, do not occur at any dose in most patients, and develop mostly unpredictably in susceptible individuals only. These reactions are generally thought to account for up to 10% of all adverse drug reactions, but their frequency may be higher depending on t...
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Idiosyncratic reactions to carbamazepine mimicking viral infection in children Adverse reactions to carbamazepine include rashes, lymphadenopathy, hepatosplenomegaly,l and bone marrow depression ranging from mild leucopenia to aplastic anaemia.2 Such reactions are rare in children. Mild leucopenia does not indicate withdrawal of the drug, but more serious bone marrow and systemic effects do. We...
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Idiosyncratic drug reactions are a significant cause of morbidity and mortality for patients; they also markedly increase the uncertainty of drug development. The major targets are skin, liver, and bone marrow. Clinical characteristics suggest that IDRs are immune mediated, and there is substantive evidence that most, but not all, IDRs are caused by chemically reactive species. However, rigorou...
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ژورنال
عنوان ژورنال: Respiration
سال: 1980
ISSN: 0025-7931,1423-0356
DOI: 10.1159/000195034